Comparison of Gastric-ulcerogenecity Effect of Methanolic Extract of Capparis spinosa and Indomethacin in Rat

Background: Several plants are used as analgesic in traditional medicine. Capparis spinosa (C. spinosa) is widely for the treatment of gout and rheumatic arthritis. The previous studies have reported antinociceptive effects this plant. Objectives: study was aimed at examining C. spinosa’s gastric-ulcerogenecity effect comparison to indomethacin. Methods: percolated extract Indomethacin were orally administered rats 50,100, 200, 400 mg/kg doses, which slaughtered after 4 hours. stomach detached, 10 mL 2% formalin injected into it fix gastric wall internal layer. then split by cutting along greater curvature, lacerations glandular section examined. J-score determine ulcer index. Results: results indicated that dosage even 2,4 8 folds did not cause a (J-score = 0) compared indomethacin 46 253) (P < 0.05). Conclusions: Concerning favorable lack ulcerogenecity effects, seems be suitable choice more pharmacological toxicology examinations use analgesic.